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Updated: Aug 15, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
Male inflammatory breast cancer
J J Spigel1, W P Evans, M D Grant
1Susan G. Komen Breast Center, Sammons Cancer Center, 3535 Worth Street, Dallas, TX 75246, USA. j.spigel@GTE.net
This case study highlights inflammatory breast cancer in a 48-year-old male, an uncommon malignancy. Early clinical and imaging findings aided diagnosis, emphasizing differentiation from benign gynecomastia.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Inflammatory breast cancer (IBC) is a rare and aggressive form of breast malignancy.
- Male breast cancer accounts for less than 1% of all breast cancers.
- Clinical differentiation from benign conditions like gynecomastia is crucial.
Observation:
- A 48-year-old male presented with clinical signs of breast thickening and erythema.
- Mammography revealed increased density, coarsened stroma, and an underlying mass in the right breast.
- Sonography identified a 2-cm ill-defined hypoechoic mass.
Findings:
- Pathologic examination confirmed infiltrating duct cell carcinoma with lobular features.
- The case illustrates the diagnostic process for male inflammatory breast cancer.
- Approximately 1500 men are diagnosed with breast cancer annually.
Implications:
- Early recognition and accurate diagnosis of male breast cancer are vital.
- Imaging modalities play a key role in differentiating malignancy from benign conditions.
- This case underscores the importance of considering breast cancer in men presenting with suspicious breast changes.
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