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Ectopic pituitary function.

J Lindholm, O Korsgaard, P Rasmussen

    Acta Medica Scandinavica
    |October 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Two patients with active acromegaly underwent hypophysectomy, but disease persisted. Ectopic pituitary tissue was suspected when pituitary function remained after surgery, suggesting a rare cause of persistent acromegaly.

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    Area of Science:

    • Endocrinology
    • Neurosurgery

    Background:

    • Acromegaly is a disorder caused by excess growth hormone (GH) production, typically from a pituitary adenoma.
    • Hypophysectomy is a surgical procedure to remove the pituitary gland, often used to treat pituitary adenomas causing acromegaly.

    Observation:

    • Two patients with persistent acromegaly after hypophysectomy were reoperated, with no pituitary tissue found during the second surgery.
    • One patient exhibited concurrent conditions including diabetes mellitus, ACTH-dependent Cushing's syndrome, and thyrotoxicosis.
    • Ectopic pituitary tissue was suspected in both patients due to persistent disease activity post-hypophysectomy.

    Findings:

    • One patient demonstrated a normal decrease in plasma GH levels in response to growth hormone-releasing hormone (GHRH), despite presumed complete hypophysectomy.

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  • The presence of residual or ectopic pituitary tissue was indicated by the continued hormonal activity and clinical manifestations of acromegaly.

    • Implications:

    • Persistent pituitary function after hypophysectomy raises suspicion for ectopic pituitary tissue.
    • This finding suggests that ectopic pituitary tissue can be a source of GH excess in acromegaly, even after pituitary gland removal.
    • Consideration of ectopic pituitary tissue is crucial for managing refractory acromegaly and associated endocrine disorders.