Analysis of the unexpected damage in children Wilm's tumor

OBJECTIVE: To explore the relationship between unexpected damage and clinical character, biological activities and molecular biology. METHODS: We treated 76 cases of children wilm's tumor from 1995 to 1998. Among them, 9 cases (11.8%) underwent unexpected damages. We studied and analyzed the clinical characters, clinical pathology, morphology and molecular biology in the 9 cases. RESULTS: Wilm's tumor in late stage, blastoma cell type and bad differentiation was likely to be damaged unexpectedly, and the outcome was poor. CONCLUSIONS: Mutation of gene is related to the biological activities. It may be a potential and important factor to cause unexpected damage.