Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Less developed corpus callosum in dyslexic subjects--a structural MRI study.

Kerstin von Plessen1, Arvid Lundervold, Nicolae Duta

  • 1Department of Child and Adolescent Psychiatry, Haukeland University Hospital, Bergen, Norway. kple@haukeland.no

Neuropsychologia
|March 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial-temporal recurrence patterns of grade 4 glioma using deep learning integrated multiparametric MRI and molecular pathology.

NPJ precision oncology·2026
Same author

Towards robust foundation models for digital pathology.

Nature communications·2026
Same author

Beyond attention heatmaps: How to get better explanations for multiple instance learning models in histopathology.

Medical image analysis·2026
Same author

Real-world data on the clinical impact of molecular tumor boards in high- and low-grade serous ovarian cancer.

Frontiers in oncology·2026
Same author

Spatially resolved ex vivo drug response profiling in SMARCB1-deficient sinonasal carcinoma.

EMBO molecular medicine·2026
Same author

[Early Detection of Systemic Amyloidosis through Routine Histological Examination in Risk Patients Undergoing Carpal Tunnel Surgery].

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2026
Same journal

Identifying Networks within an fMRI Multivariate Searchlight Analysis.

Neuropsychologia·2026
Same journal

Modulating sentence comprehension in people with aphasia through anodal tDCS: A double-blind randomized cross-over study.

Neuropsychologia·2026
Same journal

Deficient processing of regularity violations during visuospatial neglect: a visual mismatch negativity study.

Neuropsychologia·2026
Same journal

Seeing is believing: mental imagery amplifies moral, emotional, and motivational responding to mentally constructed hypothetical events.

Neuropsychologia·2026
Same journal

From Past Recall to Future Projection: What Does Verb Tense Production Reveal About Mental Time Travel in Alzheimer's disease?

Neuropsychologia·2026
Same journal

Eye Movement Measures of Word-Level and Text-Level Fluency in Disordered Reading: A Comparison of Schizophrenia and Dyslexia.

Neuropsychologia·2026
See all related articles

Boys with dyslexia show a distinct posterior corpus callosum (CC) shape difference, specifically a shorter shape in the posterior midbody/isthmus region, impacting auditory processing and literacy acquisition.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Medical Imaging

Background:

  • Dyslexia is characterized as an auditory phonological decoding disorder.
  • Previous research suggests potential structural differences in the brain, specifically the corpus callosum (CC), in individuals with dyslexia.

Purpose of the Study:

  • To investigate if the shape of the posterior corpus callosum (CC) differs between boys with developmental dyslexia and typically developing controls.
  • To identify specific regions of the CC that may exhibit shape variations related to dyslexia.

Main Methods:

  • A cohort of 20 right-handed boys with developmental dyslexia and a matched control group (mean age 11 years) were recruited.
  • Manual tracing of the CC contour on midsagittal MRI slices was performed.
  • Statistical shape analysis using a novel shape model method was employed to compare CC shape and classify subjects.

Related Experiment Videos

Main Results:

  • Statistical shape analysis revealed a significantly shorter CC shape in the dyslexic group, localized to the posterior midbody/isthmus region.
  • This posterior CC region contains fibers connecting auditory cortices, crucial for phonological processing.
  • A shorter posterior CC shape correctly discriminated between dyslexic and control subjects in 78% of cases, though overall CC area and subregion sizes did not differ significantly.

Conclusions:

  • A distinct shape difference in the posterior midbody of the corpus callosum (CC) was identified between dyslexic and control boys.
  • This finding aligns with studies showing significant CC growth in this region during late childhood, coinciding with literacy development.
  • The dyslexic group appears to exhibit an atypical growth pattern in the posterior CC compared to typically reading peers.