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Updated: Jul 6, 2026
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling
Leslie A Saxon1, Teresa De Marco, Jill Schafer
1Cardiomyopathy and Arrhythmia Research and Education Center, University of California, San Francisco, Calif, USA. saxon@medicine.ucsf.edu
Background:
Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated.
Methods And Results:
Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved.
Conclusions:
Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.
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