Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution of white matter lesions.

Reinhold Schmidt1, Helena Schmidt, Peter Kapeller

  • 1Department of Neurology, Karl Franzens University, Graz, Austria. reinhold.schmidt@kfunigraz.ac.at

Cerebrovascular Diseases (Basel, Switzerland)
|March 20, 2002
PubMed
Summary

White matter lesion progression occurred in 17.9% of older adults over 3 years. Diastolic blood pressure and baseline lesion severity predicted progression, with potential genetic factors identified.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.

HGG advances·2026
Same author

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.

medRxiv : the preprint server for health sciences·2026
Same author

Polygenic prediction of body mass index and obesity through the life course and across ancestries.

Nature medicine·2025
Same author

Age-related dynamics of predominant methanogenic archaea in the human gut microbiome.

BMC microbiology·2025
Same author

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

Research square·2025

Area of Science:

  • Neurology
  • Geriatrics
  • Radiology

Background:

  • White matter lesions (WML) are common in aging and can indicate cerebrovascular disease.
  • Understanding WML progression and its predictors is crucial for stroke prevention in the elderly.
  • Previous research has limited data on WML progression in individuals without pre-existing neuropsychiatric conditions.

Purpose of the Study:

  • To investigate the rate, clinical predictors, and cognitive consequences of MRI-detected white matter lesion (WML) progression.
  • To identify genetic susceptibility factors associated with WML progression.
  • To examine the relationship between WML progression and cognitive performance over time.

Main Methods:

  • A 3-year follow-up study of 273 participants (mean age 60) from the Austrian Stroke Prevention Study.

Related Experiment Videos

  • Assessment of brain MRI for white matter hyperintensities (WMH) at baseline and follow-up.
  • Analysis of clinical factors (e.g., blood pressure) and genetic polymorphisms (e.g., paraoxonase, angiotensinogen) as predictors of WML progression.
  • Neuropsychological testing to evaluate cognitive function.

    • Main Results:

    • WML progression was observed in 17.9% of participants over 3 years.
    • Diastolic blood pressure and baseline confluent WMH were significant predictors of WML progression.
    • Genetic associations were found with the paraoxonase Leu54Met polymorphism and the angiotensinogen M235T polymorphism.
    • No significant influence of WML progression on cognitive test performance was detected, though statistical power was limited.

    Conclusions:

    • WML progression is a notable phenomenon in older adults without neuropsychiatric disease.
    • Clinical factors like diastolic blood pressure and baseline WMH severity are key predictors.
    • Genetic factors may play a role in WML progression.
    • Further research with higher statistical power is needed to clarify the cognitive impact of WML progression.