Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Faster haplotype frequency estimation using unrelated subjects.

Jing Hua Zhao1, Pak Chnng Sham

  • 1Department of Psychological Medicine, Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK. j.zhao@iop.kcl.ac.uk

Human Heredity
|March 20, 2002
PubMed
Summary

This study introduces a faster method for linkage disequilibrium (LD) analysis, crucial for identifying disease-associated genetic variants. The enhanced computational efficiency benefits genetic research, particularly in complex diseases like schizophrenia and alcoholism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.

Cell·2026
Same author

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature genetics·2024
Same author

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Nature genetics·2023
Same author

Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Nature immunology·2023
Same author

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Nature immunology·2023
Same author

Genetic insights into resting heart rate and its role in cardiovascular disease.

Nature communications·2023

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical genetics

Background:

  • Linkage disequilibrium (LD) analysis between tightly linked loci is vital for fine-mapping disease-predisposing allelic variants.
  • Current LD analysis methods, often using unrelated cases and controls, can be computationally intensive, especially for diseases with unknown inheritance patterns.
  • Previous model-free and permutation tests, while applicable to polymorphic loci, required significant computational resources.

Purpose of the Study:

  • To accelerate computationally intensive LD analysis procedures.
  • To improve the efficiency of gene-counting and permutation tests for genetic association studies.
  • To enable rapid calculation of permutation-based LD measures and related statistics.

Main Methods:

  • Proposed a speed-up for both the gene-counting and permutation procedures in LD analysis.

Related Experiment Videos

  • Implemented an improved method for analyzing genetic association.
  • Developed a tool for rapid calculation of permutation-based LD measures.

    • Main Results:

    • Demonstrated a significant speed improvement in LD analysis procedures.
    • Successfully applied the enhanced method to analyze schizophrenia with human leucocyte antigen (HLA) markers.
    • Applied the improved method to analyze alcoholism with mitochondrial aldehyde dehydrogenase (ALDH2) markers.

    Conclusions:

    • The developed method significantly enhances the computational efficiency of LD analysis.
    • This acceleration facilitates the fine-mapping of disease-associated variants, particularly for complex genetic disorders.
    • The implementation allows for rapid calculation of crucial LD statistics, aiding genetic research.