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The linkage information content value of polymorphism genetic markers in model-free linkage analysis
Xiuqing Guo1, Jane M Olson, Robert C Elston
1Division of Medical Genetics, Department of Medicine and Pediatrics, Spielberg Pediatrics Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048, USA. Xiuqing.Guo@cshs.org
Abstract:
Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them.