[Structural alterations in erythrocyte membranes in patients with myocardial infarction]

The patients with myocardial infarction have marked changes in the structure of both protein and lipid parts of the membrane. These changes are connected with destruction of antioxide cell protection against the background of developing hypoxia and "oxide stress". In such patients the increase in HbA2 and HbF factors may be regarded as the adaptive mechanism of hypoxia conditions that develop due to decrease in myocardial propulsive ability and deterioration of blood rheological properties. Change of structural and functional characteristics of erythrocyte membranes leads to increase in their hardness that is connected with the increase in blood viscosity, pressure upon the impaired myocardium and extension of necrotic zones. Similar structures of erythrocyte and cardiomyocyte membranes allow to draw a conclusion about the presence of similar disorders in the latter membranes. It shows the necessity to introduce into the treatment scheme of myocardial infarction patients the drugs inhibiting lipid oxidation.