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Maximizing retention in community-based clinical trials.

Linda Lindsey Davis1, Marion E Broome, Ruth P Cox

  • 1Room 410, School of Nursing, 1701 University Blvd., University of Alabama at Birmingham, Birmingham, AL 35294-1210, USA. davisL@son.uab.edu

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
|March 21, 2002
PubMed
Summary

Effective participant retention in community-based clinical trials often requires a combination of strategies. Documenting retention methods and outcomes is crucial for future research credibility.

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Area of Science:

  • Clinical Trials
  • Public Health Research
  • Community-Based Research

Background:

  • Community-based clinical trials are essential for generalizable health findings.
  • Participant retention is a critical factor for trial validity and credibility.
  • Effective strategies for maintaining participant engagement are vital.

Purpose of the Study:

  • To identify and evaluate retention strategies used in community-based clinical trials over a decade.
  • To assess the effectiveness of various retention methods in published literature.
  • To highlight the importance of documenting retention outcomes in clinical research.

Main Methods:

  • Conducted comprehensive online and hand searches for reports from 1990-1999.
  • Analyzed 87 reports from 64 distinct trials.

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  • Focused on 21 reports detailing both retention strategies and their outcomes, rank-ordered by retention rates.

    • Main Results:

    • Highest retention rates in community-based trials were associated with the implementation of multiple retention strategies.
    • A combination of approaches proved more effective than single methods, despite variations in study designs.
    • Successful retention was observed across diverse study populations and intervention types.

    Conclusions:

    • Increased emphasis on clinical trials necessitates robust participant retention for credible and generalizable findings.
    • A significant gap exists in published reports detailing both retention strategies and outcomes.
    • Future research must prioritize comprehensive documentation of retention efforts and their impact.