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Updated: Oct 2, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
[Theoretical studies of QTL analysis of complex genetic diseases in humans]
Zhong-Li Hu1, Wei-Guo Dong, Yun-Chun Song
1Key Laboratory of MOE for Developmental Biology, Wuhan University, Wuhan 430072, China.
Abstract:
Some genes controlling human diseases have been located on the regions less than 1 cM using linkage disequilibrium, and a few of them have been cloned. Z. W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus (QTL), and raised the theoretical strategies for high-resolution mapping of complex genetic disorders in humans. Based on the data mentioned above, a method for linkage test between a marker locus and QTL was set up, and a method for linkage test between two marker loci and epistatic QTL was suggested for the first time.
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