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Meal interference with antibiotics administered orally in hospitals
American Journal of Hospital Pharmacy
|October 1, 1975
Summary
Many hospitals administer oral antibiotics near meal times, hindering absorption. Implementing formal dosage schedules can reduce this meal interference, improving antibiotic effectiveness.
Area of Science:
- Pharmacology
- Hospital Administration
- Clinical Pharmacy
Background:
- Optimal oral antibiotic absorption is frequently compromised by administration timing relative to meals.
- Existing drug administration schedules in hospitals show significant variability.
- Understanding meal interference is crucial for effective antibiotic therapy.
Purpose of the Study:
- To assess drug administration and meal serving times in New York City hospitals.
- To determine the frequency of oral antibiotic administration coinciding with meals.
- To identify the entities responsible for setting drug administration schedules.
Main Methods:
- A structured, disguised questionnaire administered via telephone survey.
- Data collected from 132 hospitals in New York City.
- Analysis of drug administration schedules, meal times, and responsibility for schedule establishment.
Main Results:
- Wide variations observed in both drug administration and meal serving times.
- Meal interference, defined as administration within 1-2 hours of a meal, occurred in 35% to 64% of cases.
- Pharmacy and therapeutics committees were most frequently responsible for setting administration times (19.2%).
Conclusions:
- Meal interference significantly impacts oral antibiotic absorption in hospital settings.
- A standardized, formal dosage schedule for oral antibiotics is recommended.
- Implementing such schedules can mitigate meal interference and enhance therapeutic outcomes.
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