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Related Concept Videos

Cell-mediated Immune Responses01:40

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: May 5, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Mantle-cell lymphoma.

I Barista1, J E Romaguera, F Cabanillas

  • 1Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.

The Lancet. Oncology
|March 21, 2002
PubMed
Summary
This summary is machine-generated.

Mantle-cell lymphoma is a distinct cancer entity originating from lymph node mantle zone cells. Research in the 1990s identified the BCL1 oncogene, clarifying its unique nature and distinguishing it from other lymphomas.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Mantle-cell lymphoma (MCL) is recognized as a distinct disease entity.
  • Its neoplastic cells originate from the mantle zone of lymph nodes.
  • These cells share characteristics with normal B-cells, including CD5, CD20, cyclin D1, and FMC7 expression.

Purpose of the Study:

  • To establish mantle-cell lymphoma as a unique disease entity.
  • To investigate the natural course and characteristics of mantle-cell lymphoma.
  • To differentiate mantle-cell lymphoma from other low-grade lymphomas.

Main Methods:

  • Morphological analysis of lymphoma cells.
  • Immunohistochemical staining with CD5, CD20, cyclin D1, and FMC7 antibodies.
  • Genetic analysis to identify disease markers, including the BCL1 oncogene.

Main Results:

  • Mantle-cell lymphoma cells exhibit specific morphological features (small to medium-sized, indented/cleaved nuclei).
  • Consistent positive staining with CD5, CD20, cyclin D1, and FMC7 antibodies.
  • Identification of the BCL1 oncogene as a marker, aiding in disease classification.

Conclusions:

  • Mantle-cell lymphoma is a distinct clinicopathological entity.
  • It is unrelated to small lymphocytic or small-cleaved-cell lymphomas.
  • The identification of BCL1 has been crucial for its characterization.