Related Experiment Videos
Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists
Rosaria Gitto1, Maria Zappal, Sarro Giovambattista De
1Dipartimento Farmaco-Chimico, Università di Messina, Italy. gittoros@pharma.unime.it
Farmaco (Societa Chimica Italiana : 1989)
|March 21, 2002
Abstract:
2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodegenerative diseases, such as ischemia and epilepsy. We synthesized a large number of 2,3-benzodiazepine derivatives, which showed anticonvulsant properties in different seizure models and a noncompetitive blockade of AMPA receptor. This article will briefly mention our work in this field and the main SAR considerations.