Related Experiment Video
Updated: Aug 14, 2026

Quantitative Comparison of cis-Regulatory Element (CRE) Activities in Transgenic Drosophila melanogaster
Published on: December 19, 2011
Extensive conservation of sequences and chromatin structures in the bxd polycomb response element among Drosophilid
Gaetano I Dellino1, Christophe Tatout, Vincenzo Pirrotta
1Department of Zoology, University of Geneva, Switzerland.
Abstract:
The Polycomb Response Element (PRE) is the nucleation site for the Polycomb silencing complexes. The sequences responsible for the recruitment of the components of the Polycomb complex are not well understood. A comparison of the bxd PRE sequences from several different Drosophila species shows that some changes have occurred during phylogeny but large blocks of sequence are conserved after a divergence of some 60 million years. We compare the PRE sequences, the sites of some known PRE binding proteins, the conservation of DNasel hypersensitive sites and relate them to the sequence of the Ultrabithorax promoter which these PREs regulate.
Related Concept Videos
Position-effect Variegation
Polytene Chromosomes
Inheritance of Chromatin Structures
Euchromatin
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Heterochromatin
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...

