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Related Experiment Videos

Blepharoclonus in multiple sclerosis.

D E Jacome1

  • 1Department of Medicine, Franklin Medical Center, Greenfield, Massachusetts, USA. dj@crocker.com

Acta Neurologica Scandinavica
|March 21, 2002
PubMed
Summary
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Researchers investigated gaze-evoked blepharoclonus (BLC) in multiple sclerosis (MS) patients. No common central nervous system lesions were found, indicating BLC

Area of Science:

  • Neuro-ophthalmology
  • Neuroimmunology
  • Neuroimaging

Background:

  • Gaze-evoked blepharoclonus (BLC) is a rare reflex associated with neurological disorders.
  • Multiple sclerosis (MS) can present with various ocular motor symptoms.

Purpose of the Study:

  • To identify common central nervous system (CNS) lesions in patients with MS and BLC.
  • To elucidate the pathogenesis of BLC in the context of MS.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to examine 11 adult MS patients with BLC.
  • Axial T1 imaging with contrast was performed on 9 patients.
  • The study searched for areas of demyelination and focal axonal atrophy (T1 black holes).

Main Results:

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  • No common CNS demyelination or T1 black holes were identified as a cause for BLC.
  • Multiple periventricular demyelination lesions were present in 10 patients.
  • Brainstem lesions were found in 4 patients, but their locations were inconsistent and sometimes transient.

Conclusions:

  • The study did not find a specific CNS lesion location or type associated with BLC in MS.
  • The pathogenesis and clinical significance of BLC in MS require further investigation.