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Related Experiment Videos

Pulsatile ventricular assist device with pericardial inner lining.

A A Leirner1, S A Hayashida, M J Maizato

  • 1Heart Institute (InCor), University of São Paulo Medical School, Brazil. aaleirn@attglobal.net

Artificial Organs
|March 21, 2002
PubMed
Summary
This summary is machine-generated.

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This study presents a pulsatile ventricular assist device (VAD) lined with preserved pericardium, eliminating the need for anticoagulants. The pericardium-lined VAD demonstrated adequate hydrodynamic performance and material integrity during extended testing.

Area of Science:

  • Biomaterials Engineering
  • Cardiovascular Device Development
  • Surgical Implant Technology

Background:

  • Preserved pericardium offers excellent mechanical properties and is non-thrombogenic, negating the need for anticoagulants.
  • Current ventricular assist devices (VADs) often require anticoagulation therapy, posing risks of bleeding and thrombosis.
  • Developing VADs with inherent hemocompatibility is crucial for improving patient outcomes.

Purpose of the Study:

  • To engineer a pulsatile ventricular assist device (VAD) utilizing preserved pericardium as the internal blood-contacting surface.
  • To leverage the non-thrombogenic and mechanical advantages of pericardium in a VAD design.
  • To assess the feasibility and performance of a pericardium-lined VAD.

Main Methods:

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  • Pericardium was tanned and shaped using a mold, then integrated with a flexible polymeric structure within rigid polyvinyl chloride (PVC) shells.
  • The assembled device, including pericardium valves, underwent static leak testing up to 300 mm Hg.
  • A 60-day continuous test in a mock loop evaluated hydrodynamic performance, with microscopic analysis of pericardium integrity.

    • Main Results:

    • The pericardium-lined VAD exhibited no air or fluid leakage under static pressure testing.
    • The device demonstrated adequate hydrodynamic performance for ventricular assistance over 60 days in a mock loop.
    • Microscopic examination revealed no damage to the pericardium, even in high-flex regions, indicating excellent material durability.

    Conclusions:

    • A pulsatile VAD fully lined with pericardium, incorporating a supportive polymeric structure, is feasible and performs adequately hydraulically.
    • The pericardium lining provides a hemocompatible surface, potentially eliminating the need for anticoagulants.
    • Further research into the biocompatibility and long-term strength advantages of this pericardium-lined VAD is warranted.