Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulsatile ventricular assist device with pericardial inner lining.

A A Leirner1, S A Hayashida, M J Maizato

  • 1Heart Institute (InCor), University of São Paulo Medical School, Brazil. aaleirn@attglobal.net

Artificial Organs
|March 21, 2002
PubMed
Summary

This study presents a pulsatile ventricular assist device (VAD) lined with preserved pericardium, eliminating the need for anticoagulants. The pericardium-lined VAD demonstrated adequate hydrodynamic performance and material integrity during extended testing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of daptomycin and vancomycin on Staphylococcus epidermidis biofilms: An in vitro assessment using fluorescence in situ hybridization.

PloS one·2019
Same author

Endothelial cell responses to castor oil-based polyurethane substrates functionalized by direct laser ablation.

Biomedical materials (Bristol, England)·2017
Same author

Continuous Wrist Blood Pressure Measurement with Ultrasound.

Biomedizinische Technik. Biomedical engineering·2013
Same author

Biocompatibility Material Test for Cardiovascular Devices using Stagnation Point Flow.

Biomedizinische Technik. Biomedical engineering·2013
Same author

Continuous blood pressure measurement with ultrasound.

Biomedizinische Technik. Biomedical engineering·2012
Same author

Flow regulation in multi branched models of blood vessels.

Biomedizinische Technik. Biomedical engineering·2012

Area of Science:

  • Biomaterials Engineering
  • Cardiovascular Device Development
  • Surgical Implant Technology

Background:

  • Preserved pericardium offers excellent mechanical properties and is non-thrombogenic, negating the need for anticoagulants.
  • Current ventricular assist devices (VADs) often require anticoagulation therapy, posing risks of bleeding and thrombosis.
  • Developing VADs with inherent hemocompatibility is crucial for improving patient outcomes.

Purpose of the Study:

  • To engineer a pulsatile ventricular assist device (VAD) utilizing preserved pericardium as the internal blood-contacting surface.
  • To leverage the non-thrombogenic and mechanical advantages of pericardium in a VAD design.
  • To assess the feasibility and performance of a pericardium-lined VAD.

Main Methods:

Related Experiment Videos

  • Pericardium was tanned and shaped using a mold, then integrated with a flexible polymeric structure within rigid polyvinyl chloride (PVC) shells.
  • The assembled device, including pericardium valves, underwent static leak testing up to 300 mm Hg.
  • A 60-day continuous test in a mock loop evaluated hydrodynamic performance, with microscopic analysis of pericardium integrity.

    • Main Results:

    • The pericardium-lined VAD exhibited no air or fluid leakage under static pressure testing.
    • The device demonstrated adequate hydrodynamic performance for ventricular assistance over 60 days in a mock loop.
    • Microscopic examination revealed no damage to the pericardium, even in high-flex regions, indicating excellent material durability.

    Conclusions:

    • A pulsatile VAD fully lined with pericardium, incorporating a supportive polymeric structure, is feasible and performs adequately hydraulically.
    • The pericardium lining provides a hemocompatible surface, potentially eliminating the need for anticoagulants.
    • Further research into the biocompatibility and long-term strength advantages of this pericardium-lined VAD is warranted.