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Published on: March 14, 2014
Long-term results in patients with onychomycosis treated with terbinafine or itraconazole
1Department of Dermatology and Venereology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki 25, Finland. hannele.heikkilä@hus.fi
Background:
Previously, a double-blind, randomized, multicentre study (LION study) compared the efficacy of continuous terbinafine 250 mg daily for 3 or 4 months with itraconazole pulse therapy 400 mg daily for 3 or 4 months. At the end of the study at week 72 terbinafine proved to be more effective.
Objectives:
To perform a 4-year follow-up of the Finnish participants in this study.
Methods:
Patients were re-examined clinically and mycologically.
Results:
Complete clinical and mycological cure with terbinafine for 4 months was 78% compared with 35% with terbinafine for 3 months, 24% with itraconazole for 4 months and 28% with itraconazole for 3 months.
Conclusions:
These results suggest that the initial treatment for onychomycosis should be a 4-month continuous course of terbinafine.
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