Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Large artery stiffness: structural and genetic aspects.

B A Kingwell1, T L Medley, T K Waddell

  • 1Alfred and Baker Medical Unit, Baker Medical Research Institute, Prahran, Victoria, Australia. b.kingwell@alfred.org.au

Clinical and Experimental Pharmacology & Physiology
|March 21, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regular brief interruptions to sitting after a high-energy evening meal attenuate glycemic excursions in overweight/obese adults.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018
Same author

Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Effects of maternal anxiety and depression during pregnancy in Chinese women on children's heart rate and blood pressure response to stress.

Journal of human hypertension·2015
Same author

Circulating vitamin D levels are associated with the presence and severity of coronary artery disease but not peripheral arterial disease in patients undergoing coronary angiography.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2015
Same author

Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance.

Cell stress & chaperones·2015
Same author

Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2014
Same journal

Relationship Between Long-Term Exposure to Airborne Particulate Matter and the Intrinsic Capacity of Middle-Aged and Older Adults in China: A Retrospective Cohort Study Based on CHARLS.

Clinical and experimental pharmacology & physiology·2026
Same journal

Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway.

Clinical and experimental pharmacology & physiology·2026
Same journal

Hypertension-Mediated Organ Damage: Pathophysiological Mechanisms, Clinical Consequences, and Implications for Early Risk Stratification.

Clinical and experimental pharmacology & physiology·2026
Same journal

Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2.

Clinical and experimental pharmacology & physiology·2026
Same journal

Noninvasively Evaluating the Cerebral Blood Flow Changes After Surgery in Adult Moyamoya Patients Using 3D Pulsed Arterial Spin Labelling MRI.

Clinical and experimental pharmacology & physiology·2026
Same journal

Targeting S100A8/A9 Ameliorates Heart Failure with Preserved Ejection Fraction by Modulating TLR4/NF-κB-Mediated Inflammation.

Clinical and experimental pharmacology & physiology·2026
See all related articles

Genetic factors influence large artery stiffness, a key predictor of cardiovascular disease. Specific gene variants (MMP-3, fibrillin-1) are linked to stiffer arteries and higher blood pressure, suggesting new therapeutic targets.

Area of Science:

  • Cardiovascular Physiology
  • Genetics
  • Biochemistry

Background:

  • Large artery stiffness is a major determinant of pulse pressure and cardiovascular mortality.
  • Factors like age, atherosclerosis, and gender contribute to arterial stiffening by affecting the artery's elastic matrix and smooth muscle cells.
  • Genetic and hormonal factors, including matrix metalloproteinases (MMPs), influence extracellular matrix proteins and account for individual differences in arterial properties.

Purpose of the Study:

  • To investigate the influence of stromelysin-1 (MMP-3) genotype on large artery stiffening in healthy individuals and patients with coronary artery disease (CAD).
  • To assess the role of genetic variation in fibrillin-1 on large artery stiffness and CAD severity.
  • To explore the contribution of genetic and hormonal modulation of extracellular matrix components to age, atherosclerotic, and gender-related differences in arterial mechanical properties.

Related Experiment Videos

Main Methods:

  • Examined the 5A/6A promoter polymorphism of stromelysin-1 (MMP-3) in 213 healthy individuals and 105 CAD patients.
  • Assessed pentanucleotide repeat polymorphism in fibrillin-1 in patients with CAD.
  • Correlated genotypes with measures of large artery stiffness, pulse pressure, systolic blood pressure, and CAD severity.

Main Results:

  • In healthy individuals, the 5A/5A MMP-3 genotype was associated with stiffer arteries and higher systolic blood pressure.
  • In CAD patients, the 2-3 fibrillin-1 genotype was linked to stiffer arteries, higher pulse pressure, and more severe disease.
  • Females show a greater age-related increase in large artery stiffness than males, potentially due to sex steroid modulation of MMPs.

Conclusions:

  • Genetic variations in MMP-3 and fibrillin-1 influence large artery stiffness and cardiovascular risk.
  • Extracellular matrix components and MMPs are modulated by genetic and hormonal factors, contributing to arterial stiffening.
  • These proteins represent potential therapeutic targets for managing age, atherosclerotic, and gender-related arterial stiffening.