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Updated: Oct 2, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Agranulocytosis associated with lamotrigine in a patient with low-grade glioma
Camilo E Fadul1, Louise P Meyer, Barbara C Jobst
1Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA. camilo.e.fadul@hitchcock.org
Purpose:
To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.
Methods:
A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.
Results:
After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.
Conclusions:
In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.