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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
Lidocaine-dependent early infantile status epilepticus with highly suppressed EEG
Yukio Sawaishi1, Tamami Yano, Masamichi Enoki
1Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@ped.med.akita-u.ac.jp
Abstract:
We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.
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