Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and its implications in cardiac ischemia/reperfusion: strategies to inhibit complement.

T Monsinjon1, V Richard, M Fontaine

  • 1INSERM U519, Rouen, France. Tiphaine.Monsinjon@University-rouen.fr

Fundamental & Clinical Pharmacology
|March 21, 2002
PubMed
Summary

Reperfusion injury involves inflammation, with complement system activation playing a key role. Inhibiting specific complement pathways may help salvage tissue during acute myocardial infarction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Tranexamic Acid for the Reduction of Blood Loss During Burn Surgery in Adults (Tranburn Study).

Annals of burns and fire disasters·2026
Same author

WORK AND QUALITY OF LIFE AFTER BURNS: SMALL BURNS, BIG CONSEQUENCES.

Annals of burns and fire disasters·2024
Same author

Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol.

The Science of the total environment·2021
Same author

Line-field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study.

Clinical and experimental dermatology·2021
Same author

Patients with atherosclerotic peripheral arterial disease have a high risk of lung cancer: Systematic review and meta-analysis of literature.

Journal de medecine vasculaire·2021
Same author

Line-field confocal optical coherence tomography of basal cell carcinoma: a descriptive study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Pathophysiology

Background:

  • Reperfusion of ischemic myocardium is vital but causes injury.
  • Reperfusion injury involves inflammation, oxygen free radicals, white blood cells, and complement activation.
  • The complement system, activated via classical, alternative, or lectin pathways, significantly contributes to reperfusion injury.

Purpose of the Study:

  • To explore the role of the complement system in myocardial reperfusion injury.
  • To identify therapeutic targets within the complement cascade for mitigating reperfusion injury.
  • To evaluate strategies for inhibiting complement activation during acute myocardial infarction.

Main Methods:

  • Review of existing literature on complement activation and reperfusion injury.

Related Experiment Videos

  • Analysis of the mechanisms by which complement components (C3a, C5a, MAC) cause damage.
  • Examination of experimental evidence for complement inhibition strategies.

    • Main Results:

    • Complement activation during reperfusion releases anaphylatoxins (C3a, C5a) and the membrane attack complex (MAC).
    • C5a attracts neutrophils, increasing inflammation and superoxide production.
    • MAC deposition on cells leads to direct tissue damage.

    Conclusions:

    • Inhibiting the complement pathway shows promise for tissue salvage in myocardial reperfusion.
    • Targeting specific points in the complement cascade offers pharmacological intervention opportunities.
    • Ideal strategies may involve maintaining C3 activity while inhibiting later complement events and targeting inhibition tissue-specifically.