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Dynamics of cAMP/cGMP in patients under a stress state

Peng Chen1, Ying Chai

  • 1The Second Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 31 0009, China.

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
|March 21, 2002
PubMed

Insights

Plasma cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels dynamically change during cardiac surgery. These variations reflect the intensity of traumatic stress experienced by patients.

Area of Science:

  • Cardiovascular Surgery
  • Physiology
  • Stress Response

Background:

  • Cardiac surgery involves significant physiological stress.
  • Cyclic nucleotides like cAMP and cGMP play roles in cellular signaling.
  • Understanding stress markers during surgery is crucial for patient management.

Purpose of the Study:

  • To examine plasma cAMP and cGMP dynamics in cardiac surgery patients.
  • To correlate these cyclic nucleotide levels with traumatic stress intensity.

Main Methods:

  • 16 patients undergoing open-heart surgery with cardiopulmonary bypass (CPB) and hypothermia were studied.
  • Plasma cAMP and cGMP were measured via radioimmunoassay at multiple perioperative time points.
  • Controls included heparinized and healthy donor blood samples.

Main Results:

  • Peak cAMP and cGMP levels were observed during CPB.
  • Plasma cAMP levels correlated with the overall operative stimulus.
  • cGMP levels were primarily linked to cardiac stimulus and CPB, showing a positive correlation with cAMP (r=0.6313, P<0.001).

Conclusions:

  • Dynamic changes in plasma cyclic ribonucleotides serve as a reference for traumatic stress intensity.
  • This finding offers a potential biomarker for surgical stress.
Abstract

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