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Translocation of tRNA during protein synthesis
Harry F Noller1, Marat M Yusupov, Gulnara Z Yusupova
1Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA. harry@nuvolari.ucsc.edu
FEBS Letters
|March 21, 2002
Abstract:
Coupled translocation of tRNA and mRNA in the ribosome during protein synthesis is one of the most challenging and intriguing problems in the field of translation. We highlight several key questions regarding the mechanism of translocation, and discuss possible mechanistic models in light of the recent crystal structures of the ribosome and its subunits.