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Updated: Oct 2, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Idiopathic widespread calcium pyrophosphate dihydrate crystal deposition disease in a young patient
Masanori Hayashi1, Tomomi Matsunaga, Hirotaka Tanikawa
1Department of Orthopaedics, Azumi General Hospital, 3207-1 Ikeda, Ikeda-cho Kitaazumi-gun, Nagano 399-8601, Japan. mhayashi@d3.dion.ne.jp
Abstract:
We report a case of generalized chondrocalcinosis in a 34-year-old man with no familial or medical history of associated diseases. Radiographs revealed calcification of the articular cartilages of the limbs, the fibrous rings around the intervertebral disks, the triangular cartilages of the wrists, and the pubic symphysis. On the basis of the presence of calcium pyrophosphate in the synovial fluid of his right ankle and generalized chondrocalcinosis, the patient was diagnosed with idiopathic calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. Nonsteroidal anti-inflammatory drugs and steroid treatment provided symptomatic relief.
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