Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microglia promote glioma migration.

Ina Bettinger1, Solon Thanos, Werner Paulus

  • 1Institute of Neuropathology, University Hospital Münster, Domagkstr. 19, 48129 Münster, Germany.

Acta Neuropathologica
|March 21, 2002
PubMed
Summary

Microglia cells significantly enhance glioma cell migration in brain tumors. These findings suggest microglia actively promote astrocytoma invasion, not just react to injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new cation- and vacancy-ordered brownmillerite in the Ba-In-Fe-O system revealing hidden order in its cubic counterpart.

Chemical communications (Cambridge, England)·2026
Same author

Impact of postoperative tumor volume and relative volume reduction to predict meningioma recurrence - a retrospective analysis.

Journal of neuro-oncology·2026
Same author

Detection of Copy-Number Variations in CNS Tumours From Off-Target Reads of Hybrid-Capture Sequencing.

Neuropathology and applied neurobiology·2026
Same author

[A novel mutation causing adult Alexander disease presenting as cervical spine tumor].

Fortschritte der Neurologie-Psychiatrie·2026
Same author

Reaction Intermediates and Oxygen Ordering Explored by In Situ Neutron Powder Diffraction during Thermal Oxidation of La<sub>2</sub>CoO<sub>4.00</sub>.

Inorganic chemistry·2026
Same author

Doping-Dependent Structural Phase Transitions, Magnetic Order, and Excess Oxygen Behavior in Nd<sub>2-</sub><i><sub><i>x</i></sub></i>Sr<i><sub><i>x</i></sub></i>NiO<sub>4+δ</sub>.

Inorganic chemistry·2025

Area of Science:

  • Neuro-oncology
  • Cell Biology
  • Tumor Microenvironment

Background:

  • Diffuse astrocytic gliomas infiltrate brain tissue and are characterized by the presence of microglial cells.
  • The pathogenetic relationship between glioma infiltration and microglial cell accumulation remains unclear.

Purpose of the Study:

  • To investigate the influence of murine microglial cells on the motility of GL261 mouse glioma cells.
  • To determine if microglia actively contribute to the invasive properties of astrocytoma cells.

Main Methods:

  • Boyden chamber assays were utilized to quantify glioma cell migration.
  • Glioma cells were incubated with and without microglial cells or microglia-conditioned medium.
  • The effect of microglial activating substances (GM-CSF, LPS) on glioma cell motility was assessed.

Main Results:

  • Glioma cell migration was initiated earlier and increased threefold after 48 hours in the presence of microglia compared to controls.
  • Microglia-conditioned medium replicated the stimulatory effect on glioma cell migration.
  • Oligodendroglia and endothelial cells showed only weak stimulation of glioma cell migration, indicating specificity of the microglial effect.
  • Microglia activating substances further augmented glioma cell motility.

Conclusions:

  • Microglia actively promote the invasive phenotype of astrocytoma cells.
  • Microglial accumulation in diffuse glial tumors is not merely a response to tissue damage but plays a functional role in tumor progression.

Related Experiment Videos