Related Experiment Videos
[Drug delivery systems for cancer chemotherapy]
1New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd, Tokyo, Japan.
Nihon Geka Gakkai Zasshi
|March 22, 2002
Abstract:
Various types of drug delivery system (DDS) for antitumor drugs have been developed to reduce severe systemic toxicities and to enhance antitumor effects by improving their pharmacokinetics. In this paper, outlines are first given of the concept and design of DDS, focusing on polymeric antitumor drugs (macromolecular prodrugs) and then describing the superior DDS effects shown in preclinical studies of DE-310, a DDS optimized for the camptothecin analogue DX-8951. Clinical trials of DE-310 are now ongoing in the USA and Europe.