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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

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Spot the differences: proteomics in cancer research.

L C Lawrie¹, J E Fothergill, G I Murray

¹University of Aberdeen, Foresterhill, UK.

The Lancet. Oncology

|March 22, 2002

Summary

Comparing cellular proteins using advanced techniques like mass spectrometry aids in identifying differences between normal and diseased tissues. This research explores novel tumor markers and therapeutic targets by analyzing protein expression profiles.

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Area of Science:

Proteomics
Molecular Biology
Biochemistry

Background:

Two-dimensional electrophoresis separates complex protein mixtures.
Mass spectrometry enables rapid and accurate protein identification.
The human genome sequence is crucial for protein characterization.

Purpose of the Study:

To compare protein profiles of normal and diseased tissues.
To identify potential tumor markers.
To discover novel therapeutic targets for cancer treatment.

Main Methods:

Utilizing two-dimensional electrophoresis for protein separation.
Employing mass spectrometry for protein characterization.
Leveraging the human genome sequence for identification.

Main Results:

Detailed comparison of protein expression between normal and diseased tissues.
Identification of specific protein differences associated with disease states.
Potential discovery of novel biomarkers for early disease detection.

Conclusions:

Advanced proteomic techniques offer insights into disease mechanisms.
This approach facilitates the search for new cancer therapies.
Understanding protein alterations is key to advancing oncology.