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A virtual look at Epstein-Barr virus infection: simulation mechanism.

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Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.

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Detection of EBV infection at the single-cell level. Precise quantitation of virus-infected cells in vivo.

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Detection and discrimination of latent and replicative herpesvirus infection at the single cell level in vivo.

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Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors.

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Related Experiment Video

Updated: Jul 17, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Epstein-Barr virus: exploiting the immune system.

D A Thorley-Lawson1

  • 1Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. david.thorley-lawson@tufts.edu

Nature Reviews. Immunology
|March 22, 2002
PubMed
Summary

Epstein-Barr virus (EBV) infects B cells, but persists in resting memory cells. Viral genes LMP1 and LMP2A enable EBV to hijack B-cell differentiation, explaining its persistence in memory cells.

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Epstein-Barr virus (EBV) infects B cells in vitro, causing proliferation.
  • In vivo, EBV establishes a persistent, quiescent infection in memory B cells.
  • The mechanism of EBV's specific targeting of memory B cells remains unclear.

Purpose of the Study:

  • To investigate how Epstein-Barr virus (EBV) achieves specific and persistent infection in resting memory B cells.
  • To explore the role of viral genes LMP1 and LMP2A in EBV's in vivo persistence.

Main Methods:

  • In vitro infection assays of B cells.
  • Analysis of B-cell differentiation pathways.
  • Investigation of viral gene expression (LMP1, LMP2A) in infected cells.

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Last Updated: Jul 17, 2026

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Published on: March 30, 2018

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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

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Main Results:

  • EBV infection in vitro drives B cells to activate and proliferate.
  • EBV establishes a quiescent infection in circulating resting memory B cells in vivo.
  • Viral genes LMP1 and LMP2A are implicated in EBV's ability to exploit B-cell differentiation pathways.

Conclusions:

  • EBV utilizes its genes LMP1 and LMP2A to manipulate normal B-cell differentiation.
  • This manipulation allows EBV-infected lymphoblasts to transition into resting memory B cells.
  • This mechanism explains EBV's specific persistence within the memory B cell compartment in vivo.