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Updated: Jul 12, 2026
09:47
Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Autoreactivity by design: innate B and T lymphocytes.
A Bendelac1, M Bonneville, J F Kearney
1Department of Molecular Biology, Princeton University, New Jersey 08544, USA. abendelac@molbio.princeton.edu
Nature Reviews. Immunology
|March 22, 2002
Summary
Innate B and T lymphocytes represent a unique immune strategy targeting self-structures, distinct from traditional foreign antigen recognition. These cells are crucial for regulating infections, tumors, and autoimmune diseases.
Area of Science:
- Immunology
- Cellular Biology
- Innate Immunity
Background:
- Innate B and T lymphocytes express semi-invariant, germ-line-encoded antigen receptors.
- Traditionally viewed separately, they now represent a distinct immune-recognition strategy.
Purpose of the Study:
- To elucidate the principles and mechanisms driving the unique development and function of innate lymphocytes.
- To highlight their role in immune regulation and their resemblance to natural killer cells.
Main Methods:
- Review of recent studies on innate lymphocyte development and function.
- Comparative analysis with natural killer cell subsets.
Main Results:
- Innate lymphocytes target conserved, stress-induced self-structures, unlike conventional lymphocytes targeting foreign antigens.
- These cells play a regulatory role in infectious, tumor, and autoimmune conditions.
Conclusions:
- Innate lymphocytes employ a distinct immune-recognition strategy.
- Understanding their development and function is key to regulating various diseases and offers insights into natural killer cell biology.
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