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Transplantation tolerance from a historical perspective.

T E Starzl¹, R M Zinkernagel

¹Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. starzlte@msx.upmc.edu

Nature Reviews. Immunology

|March 22, 2002

Summary

Transplantation immunology evolved from bone marrow transplants to organ engraftment. This work unifies concepts of allograft acceptance and acquired tolerance for improved clinical therapies.

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Area of Science:

Transplantation immunology
Immunology
Transplant science

Background:

The field of transplantation immunology originated from experimental bone marrow transplantation models.
Historically, human organ engraftment was believed to involve mechanisms distinct from bone marrow transplantation.

Observation:

Organ engraftment in humans predates the understanding of bone marrow transplantation feasibility.
Early research assumed divergent mechanisms for bone marrow and organ transplantation acceptance.

Findings:

This review presents a historical perspective on allograft acceptance and acquired tolerance.
The authors propose unifying rules to bridge the understanding of different transplant types.

Implications:

These unifying concepts aim to guide advancements in clinical transplantation therapies.
A cohesive understanding of transplant acceptance could lead to more effective treatments.

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