Journal of controlled release : official journal of the Controlled Release Society·2013
Excessive vitamin A and vitamin ADE in Labrador pups caused weight loss, pain, and growth issues. Vitamin ADE appeared less toxic than vitamin A alone, showing fewer severe effects in the study.
Area of Science:
Veterinary Medicine
Toxicology
Canine Health
Background:
Vitamin A is essential for canine health, but excessive intake can lead to toxicity.
Vitamin ADE (A, D, E) supplementation is common, but its comparative toxicity to vitamin A alone is less understood.
Purpose of the Study:
To investigate the toxic effects of excessive vitamin A and vitamin ADE in young dogs.
To compare the toxicity profiles of vitamin A and vitamin ADE when administered in excess.
Main Methods:
Nine mixed Labrador Retriever pups were administered excessive doses of vitamin A or vitamin ADE.
Clinical signs, radiographic changes, and pathological findings were systematically evaluated.
Main Results:
Both excessive vitamin A and vitamin ADE induced clinical signs including weight loss, dullness, emaciation, poor coat quality, joint pain, and stunted growth.
Radiographic findings revealed decreased bone length and thickness, osteophyte development, periosteal reactions, and premature epiphyseal closure.
Pathological changes included degenerative epiphyseal plates, periosteal hemorrhage and proliferation, fatty liver, and renal microcalculi.
The toxic effects of excessive vitamin A were less pronounced when administered as part of vitamin ADE.
Conclusions:
Excessive intake of vitamin A and vitamin ADE can cause significant skeletal and systemic toxicity in young dogs.
Vitamin ADE may offer a safer profile compared to vitamin A alone at excessive doses, warranting further investigation into optimal supplementation levels.
