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Updated: Oct 2, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine
Olivier Blond1, Francis Crépel, Satoru Otani
1FRE 2371 Neurobiologie des Processus Adaptatifs UMR 7102, Université de Paris VI, case 8, Building B, 6th floor, 7, quai Saint Bernard, 75005 Paris, France.
Abstract:
We have previously shown that coupling bath application of dopamine with 50 Hz tetani induces long-term depression in rat prefrontal slices [Neuroscience 85 (1998) 669]. Here, we report a reliable protocol for inducing long-term potentiation in the same preparation. Long-term potentiation was induced by the same dopamine-tetani coupling protocol when the coupling was preceded (approximately 30 min) by a single bath application of dopamine. We suggest that metaplastic processes triggered by the first application of dopamine might underlie the LTP induction.
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