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Related Experiment Videos

Injectable silicone implants as vaccine delivery vehicles.

S A Lofthouse1, M Kajihara, S Nagahara

  • 1Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, 3010 Vic., Australia. sal@unimelb.edu.au

Vaccine
|March 22, 2002
PubMed
Summary
This summary is machine-generated.

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Injectable silicone implants effectively delivered antigens in sheep, with covered rod implants providing enhanced, long-lasting antibody responses compared to conventional vaccines. These novel vaccine delivery systems show promise for improved animal immunization strategies.

Area of Science:

  • Veterinary immunology
  • Biomaterials science
  • Vaccinology

Background:

  • Injectable silicone implants offer potential as sustained-release vaccine delivery vehicles.
  • Previous in vitro studies demonstrated antigen release profiles for matrix and covered rod implants.

Purpose of the Study:

  • To evaluate injectable silicone implants as vaccine delivery systems in sheep.
  • To compare the immunogenicity and duration of antibody responses induced by two implant types against model antigens and clostridial toxoids.

Main Methods:

  • Sheep were vaccinated using matrix or covered rod silicone implants containing model antigen (avidin) or clostridial toxoids, with or without adjuvant (recombinant ovine interleukin-1beta; rovIL-1beta).
  • Antibody responses, including IgG isotypes, were measured and compared to conventional aluminum hydroxide adjuvant (alum) vaccination.

Related Experiment Videos

  • Implant preparation avoided harsh conditions (temperature, pH, organic solvents).

    • Main Results:

    • Matrix implants induced responses comparable to alum, while covered rod implants significantly enhanced antibody titres and prolonged response duration.
    • Covered rod implants promoted a balanced IgG1 and IgG2 response, unlike alum or matrix implants where IgG1 predominated.
    • Clostridial vaccination with covered rod implants achieved up to 4-fold higher protective antibody titres than alum controls.
    • All implant responses were dependent on adjuvant inclusion.

    Conclusions:

    • Injectable silicone implants, particularly the covered rod type, are effective vaccine delivery vehicles in sheep, inducing superior and prolonged antibody responses.
    • The covered rod implant's zero-order release profile is advantageous for long-term immunity and balanced isotype production.
    • Silicone implants represent a promising alternative to conventional vaccination methods in veterinary medicine.