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DTPw-HB and Hib primary and booster vaccination: combined versus separate administration to Latin American children

José Ignacio Santos1, Amando Martin, Tirza De Leon

  • 1Departamento de Medicina Experimental, Facultad de Medicina UNAM and Conrejo Nacional de Vacunación, Ministry of Health, Mexico. jisantos@supernet.com.mx

Vaccine
|March 22, 2002
PubMed

Insights

This study found that combining diphtheria, tetanus, pertussis, hepatitis B (HB), and Haemophilus influenzae type b (Hib) vaccines is safe and effective. Both mixed and separate injections provide excellent protection against these diseases in children.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Immunology

Background:

  • Childhood vaccination programs aim to prevent serious infectious diseases.
  • Combination vaccines simplify administration and improve coverage.
  • Assessing the safety and efficacy of combined DTPw-HB/Hib vaccines is crucial.

Purpose of the Study:

  • To evaluate the reactogenicity and immunogenicity of a combined diphtheria, tetanus, pertussis whole-cell-hepatitis B/Haemophilus influenzae type-b (DTPw-HB/Hib) vaccine.
  • To compare a syringe mix formulation with separate injections of the DTPw-HB/Hib vaccine.
  • To assess antibody persistence and response to booster doses.

Main Methods:

  • A multicentre study involving 400 Latin American children.
  • Administration of DTPw-HB/Hib vaccine either as a syringe mix or separate injections.
  • Monitoring of reactogenicity and measurement of antibody concentrations (anti-HBs, anti-PRP) post-primary and post-booster vaccination.

Main Results:

  • Both vaccine regimens were equally well tolerated.
  • Post-primary vaccination achieved near 100% seropositivity for all five antigens.
  • Seroprotective antibody levels for hepatitis B (HB) and Haemophilus influenzae type b (Hib) persisted for approximately one year.
  • Booster vaccination significantly increased all antibody concentrations.

Conclusions:

  • The combined DTPw-HB/Hib vaccine, whether administered as a mix or separate injections, is safe and immunogenic.
  • This combination vaccine is an effective strategy for enhancing childhood immunization coverage.
  • High and persistent antibody levels indicate long-term protection against targeted diseases.

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