Related Experiment Videos
Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication
Todd M Allen1, Lorenzo Mortara, Bianca R Mothé
1Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
Journal of Virology
|March 22, 2002
Abstract:
The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.