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Related Experiment Videos

Vessel wall reaction after vena cava filter placement.

Arend Hoekstra1, Jan M Elstrodt, Peter G J Nikkels

  • 1Bio-Medical Technology Center, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Cardiovascular and Interventional Radiology
|March 22, 2002
PubMed
Summary

The Cordis Keeper filter showed good tolerance in pigs, but long-term use may increase the risk of caval wall penetration due to filter span expansion in smaller inferior vena cava (IVC) vessels.

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Area of Science:

  • Vascular surgery
  • Medical device evaluation
  • Histopathology

Background:

  • Inferior vena cava (IVC) filters are used to prevent pulmonary embolism.
  • Long-term interaction between IVC filters and the vessel wall requires further investigation.

Purpose of the Study:

  • To evaluate the interaction between the Cordis Keeper vena caval filter and the vessel wall in a porcine model.

Main Methods:

  • Implantation of the Cordis Keeper filter in five pigs.
  • Collection of radiologic data on IVC diameter, filter patency, leg span, and stability.
  • Histopathologic analysis of the IVC wall at 2 or 6 months post-implantation.

Main Results:

  • All filters remained patent without migration.

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  • At 6 months, two filter legs penetrated the vessel wall and adhered to the liver.
  • A gradual increase in filter span correlated with increased risk of caval wall penetration, particularly in smaller IVCs (average diameter 16 mm).

    • Conclusions:

    • The Cordis Keeper filter was well tolerated in the short term.
    • Long-term use may pose a risk of caval wall penetration.