Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tacrolimus in dermatology.

Q H Dé Tran1, E Guay, S Chartier

  • 1Centre Hospitalier de l'Université de Montréal (CHUM), Campus Notre-Dame, 1560 Sherbrooke East, Montreal, Quebec, Canada H2L 4M1.

Journal of Cutaneous Medicine and Surgery
|March 22, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enlarged ulcerated tonsil and bilateral multiple enlarged neck nodes.

European annals of otorhinolaryngology, head and neck diseases·2019
Same author

Colonization of the middle turbinate.

European annals of otorhinolaryngology, head and neck diseases·2017
Same author

Intravenous butorphanol administration reduces intrathecal morphine-induced pruritus after cesarean delivery: a randomized, double-blind, placebo-controlled study.

Journal of anesthesia·2012
Same author

[Acne vulgaris].

Canadian family physician Medecin de famille canadien·2011
Same author

Validation of an internal method for the diagnosis of infections with Chlamydophila abortus and Coxiella burnetii by real-time multiplex PCR.

Developments in biologicals·2006
Same author

Anti-apoptotic effect of insulin on normal hepatocytes in vitro and in vivo.

Apoptosis : an international journal on programmed cell death·2004
Same journal

'Cockade' or 'Targetoid' Variant of Syphilis.

Journal of cutaneous medicine and surgery·2026
Same journal

Tinea Imbricata.

Journal of cutaneous medicine and surgery·2026
Same journal

Intergenerational Clouston Syndrome.

Journal of cutaneous medicine and surgery·2026
Same journal

Herpes Zoster Ophthalmicus-Associated Trigeminal Trophic Syndrome.

Journal of cutaneous medicine and surgery·2026
Same journal

Borderline Lepromatous Leprosy Presenting Solely as a Nasal Plaque.

Journal of cutaneous medicine and surgery·2026
Same journal

Efficacy and Safety of Topical 1.5% Ruxolitinib for Chronic Hand Eczema in Real‑World Practice.

Journal of cutaneous medicine and surgery·2026
See all related articles

Tacrolimus, an immunosuppressant, shows promise in treating various skin conditions like psoriasis and dermatitis. Further research is needed for rare diseases like pyoderma gangrenosum.

Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Tacrolimus (FK 506) is an immunosuppressive drug derived from Streptomyces tsukubaensis.
  • It inhibits key cytokines like IL-2, IL-3, IL-4, TNFa, and GM-CSF.
  • Tacrolimus offers greater potency and fewer side effects than cyclosporine, making it a subject of significant interest.

Purpose of the Study:

  • To evaluate the efficacy of tacrolimus in various dermatological conditions.
  • To explore its potential in treating psoriasis, dermatitis, and hair growth disorders.
  • To assess its role in preventing skin graft rejection and managing autoimmune skin diseases.

Main Methods:

  • Clinical trials involving oral and topical tacrolimus administration.
  • Placebo-controlled, double-blind studies for psoriasis treatment.

Related Experiment Videos

  • Animal studies investigating effects on hair growth, skin graft rejection, and disease models.

    • Main Results:

    • Oral tacrolimus (0.1 mg/kg/day) effectively controlled recalcitrant psoriasis lesions.
    • Topical tacrolimus demonstrated positive results in acute contact dermatitis and atopic dermatitis in humans.
    • Animal studies indicated tacrolimus promotes anagen hair growth and offers protection against chemotherapy-induced alopecia.

    Conclusions:

    • Tacrolimus shows significant therapeutic potential in managing psoriasis and various forms of dermatitis.
    • While promising in animal models for graft rejection and dermatoses, its application requires further investigation.
    • Case reports suggest efficacy in rare conditions like pyoderma gangrenosum, Sezary's syndrome, and Behcet's disease, though these remain anecdotal.