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Microscopic acanthosis nigricans in type 2 diabetes
R M McManus1, R Gottschalk, K Alanen
1Division of Endocrinology and Metabolism, Department of Medicine, The University of Western Ontario, London, Ontario, Canada. ruth.mcmanus@lhsc.on.ca
Journal of Cutaneous Medicine and Surgery
|March 22, 2002
Summary
Acanthosis nigricans (AN) prevalence was similar in type 2 diabetes patients and controls. Fasting insulin predicted AN in controls, but not in diabetes patients, highlighting unique predictors in this population.
Area of Science:
- Endocrinology
- Dermatology
- Metabolic Syndrome
Background:
- Acanthosis nigricans (AN) is linked to insulin resistance.
- Type 2 diabetes (DM) patients exhibit insulin resistance, suggesting a potential for AN.
- Prevalence and predictors of AN in DM patients remain unclear.
Purpose of the Study:
- Compare microscopic and clinical AN in Type 2 Diabetes (DM) patients versus matched controls (C).
- Assess body habitus, insulin, glucose, and androgen levels in both groups.
- Identify predictors of AN in DM patients.
Main Methods:
- Compared 24 DM patients with 24 matched controls (12M/12F each).
- Measured fasting glucose, insulin, SHBG, androgens, and testosterone.
- Recorded height, weight, waist/hip ratio, and performed clinical AN survey and skin biopsy.
Main Results:
- AN prevalence was 12% in controls and 21% in DM patients (not significant).
- In controls, AN was predicted by waist circumference, waist/hip ratio, and fasting insulin.
- No variables significantly predicted AN in the DM group.
Conclusions:
- Microscopic AN prevalence did not significantly differ between DM patients and controls.
- Fasting insulin was a strong predictor of AN in controls.
- No significant predictors of AN were identified in the DM population.