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Updated: Jul 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Epidermolysis bullosa acquisita responsive to dapsone therapy
1Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Background:
Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy.
Objective:
A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla, and direct and indirect immunofluorescence studies were consistent with EBA. The patient failed respond to niacinamide and tetracycline and oral prednisone 40 mg per day.
Methods:
Complete control of his blistering was achieved within two months of initiating oral dapsone, 150 mg per day.
Conclusion:
Dapsone may be an effective agent for some patients with EBA.
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