Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Severe pustular and polymorphous vasculitis caused by losartan].

C Piérard Franchimont1, F Henry, G E Piérard

  • 1Service de Dermatopathologie, CHU du Sart Tilman, Liège, Belgique.

Annales De Dermatologie Et De Venereologie
|March 23, 2002
PubMed
Summary

Severe pustular vasculitis, a rare skin reaction, was likely caused by the antihypertensive drug losartan. Prompt withdrawal of losartan and corticosteroid treatment led to lesion resolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal exposure of carbon dioxide ice on the nucleus of comet 67P/Churyumov-Gerasimenko.

Science (New York, N.Y.)·2016
Same author

Mechanical properties of primary anetoderma in a child.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2016
Same author

Exposed water ice on the nucleus of comet 67P/Churyumov-Gerasimenko.

Nature·2016
Same author

Seminal fluid promotes in vitro sperm-oviduct binding in the domestic cat (Felis catus).

Theriogenology·2015
Same author

Cometary science. The organic-rich surface of comet 67P/Churyumov-Gerasimenko as seen by VIRTIS/Rosetta.

Science (New York, N.Y.)·2015
Same author

Effects of chemical stress and food limitation on the energy reserves and growth of turbot, Scophthalmus maximus.

Environmental science and pollution research international·2014

Area of Science:

  • Dermatology
  • Pharmacology
  • Immunology

Background:

  • Losartan is an angiotensin II receptor blocker used to treat hypertension.
  • Cutaneous side effects of losartan are rarely reported.
  • This case highlights a severe dermatological reaction potentially linked to losartan.

Observation:

  • A 64-year-old woman presented with a rapidly progressing bullous and pustular eruption.
  • The patient was taking losartan for hypertension and no other medications.
  • Skin biopsy revealed leucocytoclastic vasculitis and junctional blisters with IgA and IgG deposits.

Findings:

  • Discontinuation of losartan and a course of corticotherapy resulted in complete resolution of the skin lesions.
  • The patient developed mottled hyperpigmentation post-eruption.

Related Experiment Videos

  • Antineutrophil cytoplasmic antibodies were present but did not correlate with recurrence.

    • Implications:

    • This case suggests losartan as a potential cause of severe, polymorphous cutaneous vasculitis.
    • Physicians should consider drug-induced vasculitis in patients presenting with similar dermatological manifestations.
    • Further investigation into the immunopathogenesis of losartan-induced skin reactions is warranted.