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Tooth-whitening efficacy and safety: a randomized and controlled clinical trial
1Division of Advanced Clinical Restorative Dentistry, Tufts University, School of Dental Medicine, Boston, Massachusetts, USA.
Compendium of Continuing Education in Dentistry. (Jamesburg, N.J. : 1995). Supplement
|March 23, 2002
Summary
This study found that a 5.3% hydrogen peroxide tooth-bleaching gel on film significantly improved tooth shade compared to placebo. The hydrogen peroxide (HP) gel offers an effective and safe at-home whitening option.
Area of Science:
- Dentistry
- Dental Materials Science
Background:
- Tooth discoloration is a common aesthetic concern.
- At-home bleaching systems aim to improve tooth shade effectively and safely.
Purpose of the Study:
- To evaluate the whitening efficacy and safety of a 5.3% hydrogen peroxide (HP) tooth-bleaching gel delivered via polyethylene film.
- To compare the efficacy of HP gel against a placebo over a 2-week period.
Main Methods:
- A randomized, single-center, double-blind, parallel-group, placebo-controlled trial.
- Participants used either 5.3% HP gel or placebo gel twice daily for two weeks.
- Efficacy was measured by changes in Vita shade scores from baseline.
Main Results:
- The HP gel group showed a mean shade score change of -3.70, significantly greater than the placebo group's -0.87 (P < 0.0001).
- The adjusted mean difference in shade change between groups was -2.85.
- Both treatments were generally well-tolerated, with HP gel strips noted for ease of use and comfort.
Conclusions:
- The 5.3% HP tooth-bleaching gel delivered on polyethylene film is effective for improving tooth shade.
- The treatment demonstrates a favorable safety profile and offers a convenient at-home whitening solution.