Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin: a novel factor in carcinogenesis.

K Gupta1, G Krishnaswamy, A Karnad

  • 1Department of Internal Medicine, Mountain Home VA Medical Center and East Tennessee State University, Johnson City, Tennessee, USA.

The American Journal of the Medical Sciences
|March 23, 2002
PubMed
Summary

Insulin may promote cancer growth by stimulating cell proliferation and inhibiting cell death. Lifestyle changes and medications that lower insulin levels could help prevent certain cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can high private cough syrup sales act as a proxy for missed TB notifications in TB surveillance?

Public health action·2025
Same author

Ultrasound-guided pulsed radiofrequency of zygomaticotemporal nerve for refractory temporal headaches.

Anaesthesia reports·2025
Same author

Heat shock protein D1 is up-regulated in various types of canine mammary tumors.

Iranian journal of veterinary research·2025
Same author

Outcome of hemiarthroplasty to total hip arthroplasty conversion: a systematic review.

Musculoskeletal surgery·2025
Same author

Molecular Characterization of δβ Thalassemia/Hereditary Persistence of Fetal Hemoglobin and Its Correlation With Clinical and Hematological Profile; a Single Center Study in North India.

International journal of laboratory hematology·2024
Same author

Detection of the <i>Mycobacterium avium</i> complex in dogs with lymphadenitis.

Iranian journal of veterinary research·2024

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Cancer remains a leading cause of mortality, with unclear causes for many types.
  • Obesity and diabetes mellitus, marked by hyperinsulinemia, correlate with increased endometrial, colorectal, and breast cancer risks.

Purpose of the Study:

  • To review the potential role of insulin as a tumor growth factor.
  • To explore mechanisms of insulin-mediated neoplasia and implications for cancer prevention.

Main Methods:

  • Review of existing scientific literature on insulin, hyperinsulinemia, and cancer.
  • Discussion of potential molecular mechanisms linking insulin to tumor development.

Main Results:

  • Evidence suggests insulin acts as a growth factor, promoting tumor formation.

Related Experiment Videos

  • Mechanisms include enhanced DNA synthesis, inhibited apoptosis, and altered sex hormone levels.
  • Reduced insulin levels through lifestyle factors (activity, weight loss, diet) may lower cancer risk.

    • Conclusions:

    • Insulin's role as a tumor growth factor warrants further investigation for cancer prevention strategies.
    • Therapeutic interventions targeting hyperinsulinemia, such as insulin-sensitizing drugs, represent a promising avenue for cancer prevention.