Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Butyltin compounds in human liver.

Jesper B Nielsen1, Jakob Strand

  • 1Institute of Public Health, University of Southern Denmark, Odense C, DK-5000, Denmark.

Environmental Research
|March 23, 2002
PubMed
Summary

Human liver samples reveal butyltin compound presence, with dibutyltin (DBT) higher than monobutyltin (MBT). Younger men show higher DBT/MBT ratios, suggesting increased susceptibility to butyltin toxicity and potential health effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreases in contaminant loads and risk of adverse effects in harbour porpoises (Phocoena phocoena) from Inner Danish waters over three decades.

Chemosphere·2026
Same author

Characteristics of patients with frequent contact with general practice: a retrospective study.

BJGP open·2025
Same author

Characteristics of patients with frequent contact with general practice.

BJGP open·2025
Same author

Do marked discharge summaries with recommendation text boxes enhance patient safety? A nationwide survey.

BJGP open·2024
Same author

Improving discharge summaries from hospital with a brief recommendation text box: results from a nationwide survey.

BJGP open·2024
Same author

Beach litter sources around Nuuk, Greenland: An analysis by UArctic summer school graduate course students.

Marine pollution bulletin·2023

Area of Science:

  • Environmental toxicology
  • Human health risk assessment
  • Organochlorine compound analysis

Background:

  • Marine food consumption is a primary route for human butyltin exposure.
  • Butyltin compounds are known to affect the immune and endocrine systems.
  • Limited data exists on human exposure levels and hepatic accumulation of butyltin compounds.

Purpose of the Study:

  • To quantify butyltin compounds (dibutyltin and monobutyltin) in human liver samples.
  • To investigate potential associations between butyltin levels, age, and the dibutyltin/monobutyltin ratio.
  • To assess the implications for human health, particularly immunotoxicity and endocrine disruption.

Main Methods:

  • Analysis of 18 human liver samples for butyltin compounds.
  • Quantification of dibutyltin (DBT) and monobutyltin (MBT) concentrations.
  • Statistical analysis to determine associations between age, DBT/MBT ratio, and exposure.

Main Results:

  • Dibutyltin (DBT) concentrations ranged from 0.8 to 28.3 ng/g (mean 9.0 ng/g).
  • Monobutyltin (MBT) concentrations were lower, ranging from 0.3 to 4.7 ng/g (mean 1.6 ng/g).
  • A significant association was found between age and the DBT/MBT ratio, with younger men exhibiting higher ratios.

Conclusions:

  • Younger men may have more recent exposures or a reduced capacity to metabolize dibutyltin (DBT).
  • This suggests potentially higher susceptibility to butyltin toxicity in younger males.
  • Inter-individual variability necessitates further research into potential immunotoxic or endocrine-disrupting effects of butyltin compounds, alone or in combination with other toxicants.

Related Experiment Videos