Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunization of complex networks.

Romualdo Pastor-Satorras1, Alessandro Vespignani

  • 1Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Campus Nord, Mòdul B4, 08034 Barcelona, Spain.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|March 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping the landscape of individual-based models for respiratory pathogen transmission in the pandemic and post-pandemic era (2020-2024): A systematic review.

Epidemics·2026
Same author

Global approaches to infectious disease surveillance and modeling.

Nature medicine·2026
Same author

Assessing the Impact of Timing and Coverage of United States COVID-19 Vaccination Campaigns: A Multi-Model Approach.

medRxiv : the preprint server for health sciences·2026
Same author

VIBES: A multiscale modeling approach integrating within-host and between-hosts dynamics in epidemics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Performance evaluation of RespiCast ensemble forecasts for primary care syndromic indicators of viral respiratory disease in Europe.

medRxiv : the preprint server for health sciences·2026
Same author

Epydemix: An open-source Python package for epidemic modeling with integrated approximate Bayesian calibration.

PLoS computational biology·2025
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

Random immunization fails to prevent epidemics in scale-free networks due to their varied connectivity. Targeted strategies focusing on highly connected individuals are essential for effective disease control in complex systems.

Area of Science:

  • Epidemiology
  • Network Science
  • Computational Biology

Background:

  • Complex networks, like the internet and social structures, exhibit high redundancy and heterogeneity.
  • This connectivity pattern creates environments conducive to the rapid spread of infectious diseases.

Purpose of the Study:

  • To evaluate the effectiveness of random uniform immunization strategies in preventing epidemic outbreaks in complex networks.
  • To investigate the impact of scale-free network properties on epidemic control.

Main Methods:

  • Analysis of epidemic spreading models on various complex network structures.
  • Simulation of random uniform immunization strategies.
  • Comparison of immunization effectiveness based on network topology, particularly scale-free networks.

Related Experiment Videos

Main Results:

  • Random uniform immunization is ineffective in eradicating infections in scale-free networks, even at high immunization densities.
  • Scale-free networks lack a critical immunization threshold due to unbounded connectivity fluctuations.
  • Targeted immunization strategies, prioritizing highly connected nodes, significantly reduce network vulnerability to epidemics.

Conclusions:

  • Random immunization is insufficient for controlling epidemics in heterogeneous networks like scale-free networks.
  • Effective epidemic control requires strategies that account for network inhomogeneity, such as targeted immunization based on node connectivity hierarchy.