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Tetany, malabsorption, and mastocytosis.

P I Dantzig

    Archives of Internal Medicine
    |November 1, 1975
    PubMed
    Summary

    Systemic mastocytosis can cause malabsorption and tetany due to mast cell infiltration of the small bowel. Early evaluation and monitoring are crucial for patients with mastocytosis to prevent these complications.

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    Area of Science:

    • Gastroenterology
    • Hematology
    • Pathology

    Background:

    • Mastocytosis is a condition defined by the abnormal proliferation of mast cells.
    • Systemic mastocytosis involves multiple organ systems, including the skin and gastrointestinal tract.

    Observation:

    • Two patients with systemic mastocytosis presented with malabsorption and tetany.
    • Absorption studies revealed small bowel involvement, with mild defects in the absence of diarrhea.
    • Small bowel biopsies showed significant mast cell infiltration, and radiographic imaging indicated bowel wall abnormalities.

    Findings:

    • Mast cell infiltration, not histamine, was identified as the cause of diarrhea and malabsorption.
    • Tetany was linked to concurrent hypocalcemia, hypomagnesemia, and hypokalemia.

    Implications:

    • Patients with systemic mastocytosis require thorough evaluation for gastrointestinal involvement.
    • Regular follow-up is essential to mitigate the risks of malabsorption and tetany in mastocytosis patients.

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