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Related Concept Videos

Protein Organization01:13

Protein Organization

Overview
Protein Folding01:22

Protein Folding

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Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Analyzing and Building Nucleic Acid Structures with 3DNA
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Protein folding and unfolding at atomic resolution.

Alan R Fersht1, Valerie Daggett

  • 1Department of Chemistry, MRC Centre for Protein Engineering, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. arf25@cam.ac.uk

Cell
|March 23, 2002
PubMed
Summary

Atomic-level protein folding is being described by combined experiment and simulation. Researchers are nearing the ability to predict protein folding events using validated simulation methods.

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Area of Science:

  • Biophysics
  • Computational Biology
  • Molecular Biology

Background:

  • Understanding protein folding is crucial for cellular processes like folding, misfolding, trafficking, and degradation.
  • Current limitations exist in predicting these complex molecular events.

Purpose of the Study:

  • To describe atomic-level protein folding events using integrated experimental and simulation approaches.
  • To advance the predictive capabilities of computational simulations for protein folding.

Main Methods:

  • Utilizing a combination of experimental data and molecular dynamics simulations.
  • Benchmarking simulation accuracy against empirical observations.

Main Results:

  • Achieving detailed, atomic-level descriptions of protein folding pathways.
  • Demonstrating the convergence of experimental and simulation data.

Conclusions:

  • Experiment and simulation are synergistically advancing the understanding of protein folding.
  • Predictive modeling of protein folding events is becoming increasingly feasible.