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Notch cleavage: Nicastrin helps Presenilin make the final cut
1University of California, Department of Molecular and Cell Biology, Berkeley 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu
Current Biology : CB
|March 23, 2002
Abstract:
Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.