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A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit
Kazuyuki Miyashita1, Myunji Park, Sayako Adachi
1Graduate School of Pharmaceutical Sciences Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 23, 2002
Abstract:
Based on the 4-hydroxy-1-azabicyclo[3.1.0]hexane structure of azinomycin, a 3,4-epoxypiperidine structure was designed as a novel and simple alkylating molecular unit, and some 3,4-epoxypiperidine derivatives were found to show DNA-cleavage activity, the structural requirements for which were revealed.